Mito-Boost Supplement & Pharmaceuticals

Traditional Chinese Medicine

1. Ginseng (Panax ginseng)

Mitochondrial Benefits: Enhances mitochondrial biogenesis, improves ATP production, antioxidant effects.

Major Companies:

• Tong Ren Tang (China - Founded 1669): Products include ginseng extracts, capsules, teas. Conducts clinical studies on energy metabolism.
• Korea Ginseng Corporation (KGC - South Korea): Brand name CheongKwanJang. Sells red ginseng extracts and supplements, with research on mitochondrial protection.
• Hsu's Ginseng Enterprises (USA/China): Specializes in both American and Asian ginseng with a focus on organic cultivation.

2. Astragalus (Huang Qi)

Mitochondrial Benefits: Protects mitochondrial membrane potential, enhances energy production.

Companies:

• Nature's Way (USA with TCM focus): Offers astragalus root capsules and tinctures, focusing on traditional use for energy support.
• Solaray (USA): Provides standardized astragalus extracts and is GMP certified.

3. Schisandra Berry (Wu Wei Zi)

Mitochondrial Benefits: Acts as a mitochondrial antioxidant and improves exercise endurance.

Companies:

• Dragon Herbs (USA/China): Founded by Ron Teeguarden, offers Schisandra extracts and adaptogenic formulas.
• Eclectic Institute (USA): Focuses on fresh herb extracts, including organic schisandra tinctures.

Ayurvedic Medicine

1. Ashwagandha (Withania somnifera)

Mitochondrial Benefits: Enhances mitochondrial function, reduces oxidative stress, and improves energy metabolism.

Major Companies:

• Himalaya Herbals (India - Founded 1930): Offers a wide range of ashwagandha products and has conducted over 300 scientific studies. GMP and organic certified.
• Banyan Botanicals (USA): Sells organic ashwagandha powders and capsules with ethical sourcing from India.
• Organic India (India): Known for Tulsi Ashwagandha supplements and regenerative agricultural practices.

2. Bacopa Monnieri (Brahmi)

Mitochondrial Benefits: Protects brain mitochondria and enhances cognitive function.

Companies:

• Himalaya Herbals: Offers Brahmi capsules and memory support formulas, researched for neuroprotective effects.
• Sri Sri Tattva (India): Provides Brahmi powders and tablets made with traditional preparation methods.

3. Turmeric/Curcumin

Mitochondrial Benefits: A powerful mitochondrial antioxidant that protects against mitochondrial dysfunction.

Companies:

• Sabinsa Corporation (India/USA): Produces Curcumin C3 Complex® with over 60 clinical studies and bioavailability-enhanced patents.
• Arjuna Natural (India): Known for BCM-95®, an enhanced bioavailability curcumin, exported to over 60 countries.

Japanese Kampo Medicine

1. Reishi Mushroom (Ganoderma lucidum)

Mitochondrial Benefits: Enhances mitochondrial energy production, provides antioxidant effects.

Companies:

• Mushroom Wisdom (USA/Japan): Offers Super Reishi extracts made with traditional Japanese preparation methods and organic cultivation.
• Aloha Medicinals (USA): Provides Reishi capsules and extracts using advanced extraction methods.

2. Japanese Knotweed (Resveratrol source)

Mitochondrial Benefits: Activates SIRT1 pathway, enhances mitochondrial biogenesis.

• Thorne Research (USA): Offers Resveratrol supplements with pharmaceutical-grade manufacturing.

Korean Traditional Medicine

1. Red Ginseng Specialists

• Korea Ginseng Corporation (KGC): Has a dedicated ginseng research institute and offers red ginseng extracts for energy and vitality.
• Ilhwa Co., Ltd. (South Korea): Innovates with fermented ginseng and novel extraction technologies.

2. Cordyceps

Mitochondrial Benefits: Enhances cellular energy production and improves oxygen utilization.

Companies:

• Aloha Medicinals: Provides Cordyceps capsules and powders, with research in athletic performance.
• Host Defense (USA): Founded by Paul Stamets, offers organic cordyceps extracts from sustainable cultivation.

Primary Mitochondrial Diseases

• MELAS Syndrome: Treated with Coenzyme Q10, L-Arginine, and Idebenone (Raxone® from Santhera Pharmaceuticals). Sonlicromanol (Khondrion) is in Phase 3.
• Leber's Hereditary Optic Neuropathy (LHON): Raxone® (Santhera Pharmaceuticals) and Lumevoq® gene therapy (GenSight Biologics) are approved in the EU.
• Barth Syndrome: Elamipretide (Stealth BioTherapeutics) has completed Phase 3 trials.

Common Diseases with Mitochondrial Links

• Parkinson's Disease: CoQ10 supplements are widely used.
• Type 2 Diabetes: Metformin and Pioglitazone (Actos®) have mitochondrial effects.
• Heart Failure: Elamipretide (Stealth BioTherapeutics) is in Phase 2 trials.

Key Companies in Mitochondrial Medicine

• Stealth BioTherapeutics: Lead candidate Elamipretide for various mitochondrial-linked diseases.
• Reneo Pharmaceuticals: Focusing on rare genetic mitochondrial diseases with REN001.
• Khondrion: Developing Sonlicromanol for MELAS syndrome.
• Santhera Pharmaceuticals: Maker of Raxone® (Idebenone) for LHON.
• GenSight Biologics: Developer of Lumevoq® gene therapy for LHON.